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Liquid–Liquid Phase Separation of α-Synuclein is Highly Sensitive to Sequence Complexity

Anindita Mahapatra and Robert W. Newberry

Protein Sci. 202433, e4951.


Fibril Treatment Changes Protein Interactions of Tau and
α-Synuclein in Human Neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson 

J. Biol. Chem. 2023, 299, 102888.


Analysis and De Novo Design of Membrane-Interactive Peptides

Huong T. Kratochvil*, Robert W. Newberry*, Bruk Mensa, Marco Mravic, and William F. DeGrado* 

Faraday Discuss. 2021, 232, 9-48.

Robust Sequence Determinants of α-Synuclein Toxicity
in Yeast Implicate Membrane Binding

Robert W. Newberry*, Taylor Arhar, Jean Costello, George C. Hartoularos, Alison M. Maxwell, Zun Zar Chi Naing, Maureen Pittman, Nishith R. Reddy, Daniel M. C. Schwarz, Douglas R. Wassarman, Taia S. Wu, Daniel Barrero, Christa Caggiano, Adam Catching, Taylor B. Cavazos, Laurel S. Estes, Bryan Faust, Elissa A. Fink, Miriam A. Goldman, Yessica K. Gomez, M. Grace Gordon, Laura M. Gunsalus, Nick Hoppe, Maru Jaime-Garza, Matthew C. Johnson, Matthew G. Jones, Andrew F. Kung, Kyle E. Lopez, Jared Lumpe, Calla Martyn, Elizabeth E. McCarthy, Lakshmi E. Miller-Vedam, Erik J. Navarro, Aji Palar, Jenna Pellegrino, Wren Saylor, Christina A. Stephens, Jack Strickland, Hayarpi Torosyan, Stephanie A. Wankowicz, Daniel R. Wong, Garrett Wong, Sy Redding, Eric D. Chow, William F. DeGrado*, and Martin Kampmann*

ACS Chem. Biol. 2020, 15, 2137–2153.

Deep Mutational Scanning Reveals the Structural Basis for α-Synuclein Activity

Robert W. Newberry, Jaime T. Leong, Martin Kampmann*, and William F. DeGrado*

Nat. Chem. Biol. 2020, 16, 653-659.

Secondary Forces in Protein Folding

Robert W. Newberry and Ronald T. Raines

ACS Chem. Biol. 2019, 14, 1677-1686.

The n→π* Interaction

Robert W. Newberry and Ronald T. Raines

Acc. Chem. Res. 2017, 50, 1838-1846.

4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins

Robert W. Newberry and Ronald T. Raines

Top. Heterocy. Chem. 2017, 48, 1-25.

A Prevalent Intraresidue Hydrogen Bond Stabilizes Proteins

Robert W. Newberry and Ronald T. Raines

Nat. Chem. Biol. 2016, 12, 1084-1088.

n→π* Interactions Are Competitive with Hydrogen Bonds

Robert W. Newberry*, Samuel J. Orke*, and Ronald T. Raines

Org. Lett. 2016, 18, 3614-3617.

Crystal Structure of N-(3-oxo­butano­yl)-L-homoserine lactone

Robert W. Newberry and Ronald T. Raines

Acta Cryst. 2016, E72, 136-139.

Thioamides in the Collagen Triple Helix

Robert W. Newberry*, Brett VanVeller*, and Ronald T. Raines

Chem. Commun. 2015, 51, 9624-9627.

n→π* Interactions Engender Chirality in Carbonyl Groups

Amit Choudhary, Robert W. Newberry, and Ronald T. Raines

Org. Lett. 2014, 16, 3421-3423.

A Key n→π* Interaction in N-Acyl Homoserine Lactones

Robert W. Newberry and Ronald T. Raines

ACS Chem. Biol. 2014, 9, 880-883.

Signatures of n→π* Interactions in Proteins

Robert W. Newberry, Gail J. Bartlett, Brett VanVeller, Derek N. Woolfson, and Ronald T. Raines

Protein Sci. 2014, 23, 284-288.

Interplay of Hydrogen Bonds and n→π* Interactions in Proteins

Gail J. Bartlett, Robert W. Newberry, Brett VanVeller, Ronald T. Raines, and Derek N. Woolfson

J. Am. Chem. Soc. 2013, 135, 18682-18688.

n→π* Interactions in poly(lactic acid) Suggest a Role in Protein Folding

Robert W. Newberry and Ronald T. Raines

Chem. Commun. 2013, 49, 7699-7701.

n→π* Interactions of Amides and Thioamides:
Implications for Protein Stability

Robert W. Newberry, Brett VanVeller, Ilia A. Guzei, and Ronald T. Raines

J. Am. Chem. Soc. 2013, 135, 7843-7846.

Role of Electrostatics in Differential Binding of RalGDS to Rap Mutations E30D and K31E Investigated by Vibrational Spectroscopy of Thiocyanate Probes

Christina M. Ragain, Robert W. Newberry, Andrew W. Ritchie, and Lauren J. Webb

J. Phys. Chem. B 2012, 116, 9326-9336.

Discrimination of Flavonoids and Red Wine Varietals by Arrays of Differential Peptidic Sensors

Alona P. Umali, Sarah E. LeBoeuf, Robert W. Newberry, Siwon Kim, Lee Tran, Whitney A. Rome, Tian Tian, David Taing, Jane Hong, Melissa Kwan, Hildegarde Heymann, and Eric V. Anslyn

Chem. Sci. 2011, 2, 439-445.

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